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 Publication List |
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英文原著論文 |
| 53. |
A. R. Shrestha, Y. Hari, A. Yahara, T. Osawa, S. Obika
Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring.
J. Org. Chem., 76, 9891-9899. (2011) |
| 52. |
Y. Hari, T. Kodama, T. Imanishi, S. Obika
2'-O,4'-C-Methyleneoxymethylene bridged nucleic acid (2',4'-BNA<sup>COC<sup>).
Therapeutic Oligonucleotides (Humana Press), 764 (Methods in Mol. Biol.), 31-57. (2011) |
| 51. |
Y. Hari, T. Aoyama, T. Shioiri
1-Diazo-1-silylalkanes.
Science of Synthesis Knowledge Update 2010/4 (Georg Thieme Verlag), 4, 25-68. (2011) |
| 50. |
Y. Hari, M. Akabane, Y. Hatanaka, M. Nakahara, S. Obika
A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA.
Chem. Commun., 47, 4424-4427. (2011) |
| 49. |
Y. Hari, M. Nakahra, J. Pang, M. Akabane, T. Kuboyama, S. Obika
Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1,2,3-triazole nucleobases.
Bioorg. Med. Chem., 19, 1162-1166. (2011) |
| 48. |
Y. Hari, S. Matsugu, H. Inohara, Y. Hatanaka, M. Akabane, T. Imanishi, S. Obika
2’,4’-BNA bearing a 2-pyridine nucleobase for CG base pair recognition in the parallel motif triplex DNA.
Org. Biomol. Chem., 8, 4176-4180. (2010) |
| 47. |
M. Morita, Y. Hari, T. Aoyama
Facile synthesis of 1-methyl-1H-benzo[b]azepines from 1-methylquinolinium iodides and diazo(trimethylsilyl)methylmagnesium bromide.
Synthesis, 4221-4227. (2010) |
| 46. |
Y. Hari, T. Yokoyama, T. Aoyama
Synthesis of 3-substituted 3-(trimethylsilyl)pyrrolidines from β-aminoketones and lithium trimethylsilyldiazomethane.
Heterocycles, 80, 679-687. (2010) |
| 45. |
Y. Hari, R. Kondo, K. Date, T. Aoyama
Facile synthesis of 2-unsubstituted benzofuran-3-carboxylates using diazo(trimethylsilyl)methylmagnesium bromide.
Tetrahedron, 65, 8708-8713. (2009) |
| 44. |
G. T. Hwang, Y. Hari, F. E. Romesberg
The effects of unnatural base pairs and mispairs on DNA duplex stability and solvation.
Nucleic Acids Res., 37, 4757-4763. (2009) |
| 43. |
Y. Hari, R. Sone, T. Aoyama
Facile two-step synthesis of 3-substituted indazoles using diazo(trimethylsilyl)methylmagnesium bromide.
Org. Biomol. Chem., 7, 2804-2808. (2009) |
| 42. |
M. Nakahara, T. Kuboyama, A. Izawa, Y. Hari, T. Imanishi, S. Obika
Synthesis and base-pairing properties of C-nucleotides having 1-substituted 1H-1,2,3-triazoles.
Bioorg. Med. Chem. Lett., 19, 3316-3319. (2009) |
| 41. |
Y. Mitsuoka, T. Kodama, R. Ohnishi, Y. Hari, T. Imanishi, S. Obika
A bridged nucleic acid, 2’,4’-BNACOC: Synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2’,4’-BNACOC monomers and RNA-selective nucleic-acid recognition.
Nucleic Acids Res., 37, 1225-1238. (2009) |
| 40. |
Y. Hari, G. T. Hwang, A. M. Leconte, N. Joubert, M. Hocek, F. E. Romesberg
Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication.
ChemBioChem, 9, 2796-2799. (2008) |
| 39. |
Y. Hari, K. Date, R. Kondo, T. Aoyama
New synthesis of t-butyl arylpropiolates using diazo(trimethylsilyl)methylmagnesium bromide.
Tetrahedron Lett., 49, 4965-4967. (2008) |
| 38. |
Y. Hari, M. Sakuma, A. Miyakawa, K. Hatano, T. Aoyama
Synthesis of chiral tetrahydroisoquinoline-derived β-amino alcohols and their application to asymmetric reaction.
Heterocycles, 76, 305-311. (2008) |
| 37. |
A. M. Leconte, G. T. Hwang, S. Matsuda, P. Capek, Y. Hari, F. E. Romesberg
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.
J. Am. Chem. Soc., 130, 2336-2343. (2008) |
| 36. |
S. Obika, H. Inohara, Y. Hari, T. Imanishi
Recognition of T・A interruption by 2',4'-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation.
Bioorg. Med. Chem., 16, 2955-2967. (2008) |
| 35. |
M. Morita, Y. Hari, T. Iguchi, T. Aoyama
Facile synthesis of 2-azaazulenes from thiobenzoyl isocyanates using trimethylsilyldiazomethane.
Tetrahedron, 64, 1753-1758. (2008) |
| 34. |
Y. Hari, K. Date, T. Aoyama
Facile one-pot synthesis of functionalized acetylenes from aryl and heteroaryl sldehydes using lithium trimethylsilyldiazomethane.
Heterocycles, 74, 545-552. (2007) |
| 33. |
Y. Hari, S. Tsuchida, R. Sone, T. Aoyama
An efficient synthesis of 2-diazo-2-(trimethylsilyl)ethanols and their application to pyrazole synthesis.
Synthesis, 3371-3375. (2007) |
| 32. |
Y. Kim, A. M. Leconte, Y. Hari, F. E. Romesberg
Stability and polymerase recognition of pyridine nucleobase analogues: Role of minor-groove H-bond acceptors.
Angew. Chem. Int. Ed., 45, 7809-7812 . (2006) |
| 31. |
Y. Hari, S. Tsuchida, T. Aoyama
One-pot, cis-selective synthesis of α-substituted β-trimethylsilyl-α,β-epoxyesters from α-ketoesters and diazo(trimethylsilyl)methylmagnesium bromide.
Tetrahedron Lett., 47, 1977-1980. (2006) |
| 30. |
Y. Hari, T. Kanie, T. Aoyama
Efficient synthesis of o-alkynyl-N-pivaloylanilines from o-acyl-N-pivaloylanilines and lithium trimethylsilyldiazomethane.
Tetrahedron Lett., 47, 1137-1139. (2006) |
| 29. |
Y. Hari, T. Kanie, T. Miyagi, T. Aoyama
One-pot synthesis of 2,3-disubstituted N-tosylindoles from o-acyl-N-tosylanilines.
Synthesis, 1249-1252. (2006) |
| 28. |
Y. Hari, S. Obika, R. Ohnishi, K. Eguchi, T. Osaki, H. Ohishi, T. Imanishi
Synthesis and properties of 2’-O,4’-C-methyleneoxymethylene bridged nucleic acid.
Bioorg. Med. Chem., 14, 1029-1038. (2006) |
| 27. |
S. Tsuchida, Y. Hari, T. Aoyama
New synthesis of t-butyl 1,2-dihydro-1-oxaazulene-3-carboxylates using lithium trimethylsilyldiazomethane.
Heterocycles, 65, 2667-2674 . (2005) |
| 26. |
Y. Hari, T. Iguchi, T. Aoyama
Facile, one-pot synthesis of bicyclic 2-pyridones from acyl isocyanates, N-phenylmaleimide and trimethylsilyldiazomethane.
Synthesis, 2147-2150. (2005) |
| 25. |
Y. Hari, S. Obika, H. Inohara, M. Ikejiri, D. Une, T. Imanishi
Synthesis and triplex-forming ability of 2’,4’-BNAs bearing imidazoles as a nucleobase.
Chem. Pharm. Bull., 53, 843-846. (2005) |
| 24. |
Y. Hari, Y. Shoji, T. Aoyama
Regioselective synthesis of 1-arylindazoles via N-arylation of 3-trimethylsilylindazoles.
Tetrahedron Lett., 46, 3771-3774 . (2005) |
| 23. |
Y. Hari, T. Aoyama
Enantioselective addition of diethylzinc to aldehydes catalyzed by (1R,2R)-10-(dialkylamino)isoborneols.
Synthesis, 583-587. (2005) |
| 22. |
T. Miyagi, Y. Hari, T. Aoyama
New synthesis of 3-substituted indoles using lithium trimethylsilyldiazomethane.
Tetrahedron Lett., 45, 6303-6305. (2004) |
| 21. |
Y. Hari, T. Iguchi, T. Aoyama
Facile one-pot synthesis of di- and tri-substituted furans from acyl isocyanates using trimethylsilyldiazomethane.
Synthesis, 1359-1362 . (2004) |
| 20. |
Y. Hari, Y. Shoji, T. Aoyama
New synthesis of 3-substituted indazoles from 3-trimethylsilylindazole.
Synthesis, 1183-1186. (2004) |
| 19. |
Y. Shoji, Y. Hari, T. Aoyama
Facile synthesis of 3-trimethylsilylindazoles by [3+2]cycloaddition reaction of lithium trimethylsilyldiazomethane with benzynes.
Tetrahedron Lett., 45, 1769-1771. (2004) |
| 18. |
Y. Hari, S. Tanaka, Y. Takuma, T. Aoyama
New two-step synthesis of azulene-1-carboxylic esters using lithium trimethylsilyldiazomethane.
Synlett, 2151-2154. (2003) |
| 17. |
Y. Hari, S. Obika, M. Sekiguchi, T. Imanishi
Selective recognition of CG interruption by 2’,4’-BNA having 1-isoquinolone as a nucleobase in a pyrimidine motif triplex formation.
Tetrahedron, 59, 5123-5128. (2003) |
| 16. |
S. Obika, O. Nakagawa, A. Hiroto, Y. Hari, T. Imanishi
Synthesis and properties of a novel bridged nucleic acid with a P3’→N5’ phosphoramidate linkage, 5’-amino-2’,4’-BNA.
Chem. Commun., 2202-2203. (2003) |
| 15. |
H. Torigoe, Y. Hari, S. Obika, T. Imanishi
Triplex formation involving 2’-O,4’-C-methylene bridged nucleic acid (2’,4’-BNA) with 1-isoquinolone base analogue: Efficient and selective recognition of C:G interruption.
Nucleosides Nucleotides and Nucleic Acids, 22, 1571-1573. (2003) |
| 14. |
H. Torigoe, Y. Hari, S. Obika, T. Imanishi
Triplex formation involving 2’-O,4’-C-methylene bridged nucleic acid (2’,4’-BNA) with 2-pyridone base analogue: Efficient and selective recognition of C:G interruption.
Nucleosides Nucleotides and Nucleic Acids, 22, 1097-1099. (2003) |
| 13. |
S. Obika, Y. Hari, M. Sekiguchi, T. Imanishi
Stable Oligonucleotide-directed triplex formation at target sites with CG interruptions: Strong sequence-specific recognition by 2’,4’-bridged nucleic acid containing 2-pyridones under physiological conditions.
Chem. Eur. J., 8, 4796-4802 . (2002) |
| 12. |
S. Obika, M. Sekiguchi, T. Osaki, N. Shibata, M. Masaki, Y. Hari, T. Imanishi
Synthesis and conformation of a novel bridged nucleoside with S-type sugar puckering, trans-3’,4’-BNA monomer.
Tetrahedron Lett., 43, 4365-4368. (2002) |
| 11. |
Y. Hari, S. Obika, M. Sakaki, K. Morio, Y. Yamagata, T. Imanishi
Effective synthesis of C-nucleosides with 2’,4’-BNA modification.
Tetrahedron, 58, 3051-3063. (2002) |
| 10. |
S. Obika, K. Morio, D. Nanbu, Y. Hari, H. Itoh, T. Imanishi
Synthesis and conformation of 3’,4’-BNA monomers, 3’-O,4’-C-methyleneribonucleosides.
Tetrahedron, 58, 3039-3049 . (2002) |
| 9. |
H. Torigoe, Y. Hari, M. Sekiguchi, S. Obika, T. Imanishi
2’-O,4’-C-Methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: Thermodynamic and kinetic studies.
J. Biol. Chem., 276, 2354-2360 . (2001) |
| 8. |
S. Obika, Y. Hari, M. Sekiguchi, T. Imanishi
A 2’,4’-bridged nucleic acid containing 2-pyridone as a nucleobase: Efficient recognition of a C+G interruption by triplex formation with a pyrimidine motif.
Angew. Chem. Int. Ed., 40, 2079-2081. (2001) |
| 7. |
S. Obika, Y. Hari, T. Sugimoto, M. Sekiguchi, T. Imanishi
Triplex-forming enhancement with high sequence selectivity by single 2’-O,4’-C-methylene bridged nucleic acid (2’,4’-BNA) modification.
Tetrahedron Lett., 41, 8923-8927. (2000) |
| 6. |
S. Obika, Y. Hari, K. Morio, T. Imanishi
Triplex formation by an oligonucleotide containing conformationally locked C-nucleoside, 5-(2-O,4-C-methylene-β-D-ribofuranosyl)oxazole.
Tetrahedron Lett., 41, 221-224. (2000) |
| 5. |
S. Obika, Y. Hari, K. Morio, T. Imanishi
Synthesis of conformationally locked C-nucleosides having a 2,5-dioxabicyclo[2.2.1]heptane ring system.
Tetrahedron Lett., 41, 215-219. (2000) |
| 4. |
S. Obika, K. Morio, Y. Hari, T. Imanishi
Preparation and properties of 2’,5’-linked oligonucleotide analogues containing 3’-O,4’-C-methyleneribonucleosides.
Bioorg. Med. Chem. Lett., 9, 515-518. (1999) |
| 3. |
S. Obika, K. Morio, Y. Hari, T. Imanishi
Facile synthesis and conformation of 3’-O,4’-C-methyleneribonucleosides.
Chem. Commun., 2423-2424. (1999) |
| 2. |
S. Obika, D. Nanbu, Y. Hari, J. Andoh, K. Morio, T. Doi, T. Imanishi
Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2’-O,4’-C-methyleneribonucleosides.
Tetrahedron Lett., 39, 5401-5404. (1998) |
| 1. |
S. Obika, D. Nanbu, Y. Hari, K. Morio, Y. In, T. Ishida, T. Imanishi
Synthesis of 2’-O,4’-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3’-endo sugar puckering.
Tetrahedron Lett., 38, 8735-8738. (1997) |
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邦文総説 |
| 4. |
張 功幸, 塩入孝之, 青山豊彦
「トリメチルシリルジアゾメタンを用いる複素環化合物の合成 」
有機合成化学協会誌, 67, 357-368. (2009) |
| 3. |
張 功幸
「アキラルリガンドの添加による不斉反応の改良」
ファルマシア, 42, 470-471. (2006) |
| 2. |
張 功幸
「キラルジオキシランを用いたα,β-不飽和エステルの不斉エポキシ化反応」
ファルマシア, 39, 447-448. (2003) |
| 1. |
今西 武、張 功幸
「超機能性人工核酸の開発に向けて」
脳21, 5, 309-314. (2002) |
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 Seminar / Symposium / Invited |
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セミナー・シンポジウム・招待講演・業績発表会 |
| 3. |
【2010/03/19】
「大阪大学生命科学若手研究アプレンティスプログラム」平成21年度業績発表会
ポスター(pdf) |
| 2. |
【2009/10/09】
「大阪大学生命科学若手研究アプレンティスプログラム」第二回シンポジウム
ポスター(pdf) |
| 1. |
【2009/02/24】
「大阪大学生命科学若手研究アプレンティスプログラム」第一回シンポジウム
ポスター(pdf) |
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 Patents / Other |
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特許・その他 |
| 1. |
「新規な架橋型人工ヌクレオシド及びオリゴヌクレオチド」
特願2009-248979 (平成21年10月)、特願2010-23209（国内優先権主張出願、平成22年2月）
WO/2011/052436 (Bridged artificial nucleoside and nucleotide) |
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Awards / Evaluation